Nina Beety Informal Objection 15

0747-EX-PL-2015 Informal Objections

Google Inc.

2016-01-13ELS_171438

http://www.ncbi.nlm.nih.gov/pubmed/26300312?dopt=Abstract Journal of Chemical Neuroanatomy J Chem Neuroanat. 2015 Aug 20. pii: S0891-0618(15)00059-9. doi: 10.1016/j.jchemneu.2015.08.001. [Epub ahead of print] Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression. Pall ML1. Author information • 1 Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University, 638 NE 41(st) Ave., Portland, OR 97232-3312, USA. Electronic address: martin_pall@wsu.edu. Abstract Non-thermal microwave/lower frequency electromagnetic fields (EMFs) act via voltage-gated calcium channel (VGCC) activation. Calcium channel blockers block EMF effects and several types of additional evidence confirm this mechanism. Low intensity microwave EMFs have been proposed to produce neuropsychiatric effects, sometimes called microwave syndrome, and the focus of this review is whether these are indeed well documented and consistent with the known mechanism(s) of action of such EMFs. VGCCs occur in very high densities throughout the nervous system and have near universal roles in release of neurotransmitters and neuroendocrine hormones. Soviet and Western literature shows that much of the impact of non-thermal microwave exposures in experimental animals occurs in the brain and peripheral nervous system, such that nervous system histology and function show diverse and substantial changes. These may be generated through roles of VGCC activation, producing excessive neurotransmitter/neuroendocrine release as well as oxidative/nitrosative stress and other responses. Excessive VGCC activity has been shown from genetic polymorphism studies to have roles in producing neuropsychiatric changes in humans. Two U.S. government reports from the 1970's-80's provide evidence for many neuropsychiatric effects of non-thermal microwave EMFs, based on occupational exposure studies. 18 more recent epidemiological studies, provide substantial evidence that microwave EMFs from cell/mobile phone base stations, excessive cell/mobile phone usage and from wireless smart meters can each produce similar patterns of neuropsychiatric effects, with several of these studies showing clear dose-response relationships. Lesser evidence from 6 additional studies suggests that short wave, radio station, occupational and digital TV antenna exposures may produce similar neuropsychiatric effects. Among the more commonly reported changes are sleep disturbance/insomnia, headache, depression/depressive symptoms, fatigue/tiredness,dysesthesia, concentration/attention dysfunction, memory changes, dizziness, irritability, loss of appetite/body weight, restlessness/anxiety, nausea, skin burning/tingling/dermographism and EEG changes. In summary, then, the mechanism of action of microwave EMFs, the role of the VGCCs in the brain, the impact of non-thermal EMFs on the brain, extensive epidemiological studies performed over the past 50 years, and five criteria testing for causality, all collectively show that various non-thermal microwave EMF exposures produce diverse neuropsychiatric effects. Copyright © 2015. Published by Elsevier B.V. KEYWORDS: Excessive calcium effects; low-intensity microwave electromagnetic fields; oxidative/nitrosative stress PMID: 26300312 [PubMed - as supplied by publisher]


Document Created: 2016-01-13 04:14:20
Document Modified: 2016-01-13 04:14:20
© 2025 FCC.report
This site is not affiliated with or endorsed by the FCC