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United States Patent | 5,500,343 |
Blum , et al. | March 19, 1996 |
In an important embodiment, the present invention concerns a method for detecting compulsive disorder susceptibility of a human. The method comprises initially obtaining a DNA sample of said human and then determining the presence or absence of a particular human D.sub.2 receptor gene allele in said sample. Detection of said allele in the sample is indicative of susceptibility to compulsive disorder. A most preferred embodiment is to detect a susceptibility to alcoholism and cocaine dependence, particularly because said allele has been found to be present in a majority of clinically diagnosed alcoholics and cocaine users. The human D.sub.2 receptor gene A1 and B1 alleles are most preferably detected in said sample.
Application Number | Filing Date | Patent Number | Issue Date | ||
826222 | Jan., 1992 | 5210016 | |||
477057 | Feb., 1990 | ||||
Current U.S. Class: | 435/6 ; 435/810; 435/91.1; 435/91.2; 536/23.1; 536/23.5; 536/24.33 |
Current International Class: | C12Q 1/68 (20060101); C12Q 001/68 (); C12P 019/34 (); C07H 021/04 (); C12N 015/00 () |
Field of Search: | 435/6,91,975,91.1,91.2,810 536/23.1,23.5,24.31,24.33 935/78,31 |
5210016 | May 1993 | Blum et al. |
Suarez et al., Genomics vol. 19, pp. 12-20 (1994). . Holden, Science, vol. 264, pp. 1696-1697, 17 Jun. 1994.. |