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United States Patent | 5,650,313 |
Ni , et al. | July 22, 1997 |
Human UCE 7, UCE 8 and UCE 9 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods of utilizing such polypeptide for the treatment of the proliferation of malignant cells. Antagonists against such polypeptides and their uses as a therapeutic to treat Alzheimer's disease, atrophying skeletal muscle, African swine fever virus and apoptotic cell death are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in UCE 7, 8 and 9 nucleic acid sequences and the concentration of polypeptides encoded by such sequences.
Inventors: | Ni; Jian (Gaithersburg, MD), Gentz; Reiner (Silver Spring, MD), Adams; Mark D. (North Potomac, MD) |
Assignee: |
Human Genome Sciences, Inc.
(Rockville,
MD)
|
Appl. No.: | 08/464,342 |
Filed: | June 5, 1995 |
Current U.S. Class: | 435/193 ; 435/252.3; 435/320.1; 435/325; 435/352; 435/357; 435/358; 435/364; 435/365; 435/367; 435/69.1; 536/23.2 |
Current International Class: | C07K 16/40 (20060101); C12N 9/00 (20060101); A61K 38/00 (20060101); C12N 009/10 (); C12N 001/20 (); C12P 021/06 (); C07H 021/04 () |
Field of Search: | 435/69.1,193,240.1,252.3,320.1 536/23.2 |
5384255 | January 1995 | Ciechanover et al. |
WO95/27066 | Oct., 1995 | WO | |||
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