( 3 of 3 ) |
United States Patent | 5,332,667 |
Kado , et al. | July 26, 1994 |
A biologically active polysaccharide RON substance which is excellent in such biological activities as antitumor activities, is produced by using a microorganism belonging to the genus Leuconostoc, which has an activity of producing the RON substance.
Inventors: | Kado; Hisao (Yaizu, JP), Yoneta; Yasuo (Yaizu, JP), Takeo; Suguru (Yaizu, JP), Mitani; Yutaka (Yaizu, JP), Watanabe; Nobuhiro (Yaizu, JP) |
Assignee: |
Sapporo Breweries Limited
(Tokyo,
JP)
|
Appl. No.: | 08/116,210 |
Filed: | September 2, 1993 |
Application Number | Filing Date | Patent Number | Issue Date | ||
912204 | Jul., 1992 | ||||
807968 | Dec., 1991 | ||||
469298 | Jan., 1990 | ||||
Feb 08, 1989 [JP] | 1-29381 | |||
Current U.S. Class: | 435/101 ; 435/183; 435/252.1; 435/822; 536/1.11; 536/123.12; 536/127; 536/55.1 |
Current International Class: | C12P 19/08 (20060101); C12P 19/00 (20060101); C08B 37/00 (20060101); C12N 001/20 (); C12P 019/04 () |
Field of Search: | 435/101,183,252.1,822 536/1.1,55.1 |
4762825 | August 1988 | Takeo et al. |
0087404 | Aug., 1983 | EP | |||
0172559 | Jun., 1987 | EP | |||
3224547 | Jan., 1984 | DE | |||
Gherna et al., ATCC Catalogue of Bacteria & Bacteriophages, 17th edition, 1989, p. 123, American Type Culture Collection. . Marina E. Preobrazhenskaya et al, Studies on Some Biologically Active Dextrans, Carbohydrate Research, 66(1978) pp. 213-223. . S. M. Navashin et al, Antitumor and Antibacterial Activity of Dextran LU-122 and Its Effect on Macrophage Activity, Curr. Chemother. Immunother., Proc. Int. Congr. Chemther, 12th, 1, pp. 190-192 (1982). . Chemical Abstracts, Jan. 2, 1989, vol. 110, 387w, Suguru et al, "Studies of an antitumor Polysaccaride RBS derived from rice bran. II Preparation and general properties of RON, an active fraction of RBS." & Chem. Pharm. Bull. 1988. . Chemical Abstracts, Oct. 29, 1973, vol.79:10174n, OLLE, "Structural studies on the extracellular polysaccharides elatorated by Leoconostoc Mesenteroides NRRL B-512 and Diplococcus pneumoniae Type II" & Chem. Commun. Univ. Stockholm 1973. . Sneath et al. "Bergey's Manual of Systematic Bateriology", 1986, vol. 2. pp. 1071-1075.. |