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United States Patent | 6,933,122 |
Role , et al. | August 23, 2005 |
This invention provides nARIA-based assays for defining whether a subject has or is predisposed to developing a neoplastic disease. This invention further provides a nARIA-based method for maintaining synaptic connections between a neuron and a target cell.
Inventors: | Role; Lorna W. (New York, NY), Talmage; David (New York, NY), Bao; Jianxin (Riverdale, NY) |
Assignee: |
The Trustees of Columbia University in the City of New York
(New York,
NY)
|
Appl. No.: | 09/312,596 |
Filed: | May 14, 1999 |
Current U.S. Class: | 435/7.1 ; 435/7.2; 435/7.92 |
Current International Class: | G01N 33/68 (20060101); G01N 33/574 (20060101); G01N 033/53 (); G01N 033/543 (); G01N 033/545 (); G01N 033/552 (); G01N 033/566 () |
Field of Search: | 435/7.1,7.2,7.92 |
5578482 | November 1996 | Lippman et al. |
5602096 | February 1997 | Goodearl et al. |
6284535 | September 2001 | Role |
Rudinger, J. In Peptide Hormones, J. A. Parsons, Ed. University Park Press, Baltimore, pp. 1-7, 1976. . Mahanthappa, N. K. et al., (Aug. 1, 1996) Glial Growth Factor 2, a Soluble Neuregulin, Directly Increases Schwann Cell Motility and Indirectly Promotes Neurite Outgrowth, J. Neuroscience 16 (15) :4673-4683, (Exhibit 2). . International Search Report from International Searching Authority for PCT International Application No. PCT/US00/13157, dated Apr. 20, 2001, (Exhibit 3). . Poster for seminar entitled "A role of HEN1 in Neurogenesis and Recent Data on Neuregulin" dated May 20, 1999, (Exhibit 4). . Bao, J. et al. (Oct. 1997) Abstract for Society for Neuroscience Meeting, CNIP: A Novel Interactor Protein Specific for the Cytoplasmic Domain of CRD Neuregulin., (Exhibit 5). . Bao, J. et al. (Oct. 1999) Abstract for Society for Neuroscience Meeting, Novel Functions of the Cytoplasmic Domain of Neuregulin. (Exhibit 6). . Wolpowitz, D. et al. (Nov. 1998) Abstract for Society for Neuroscience Meeting, CRD-NRG In Mouse Peripheral Nervous System Development, (Exhibit 7). . Yang, X, et al. (Feb. 1998) A Cysteine-Rich Isoform of Neuregulin Controls the Level of Expression of Neuronal Nicotinic Receptor Channels During Synaptogenesis, Neuron, 20:255-270, (Exhibit 8). . Chu, G.C. et al., (1995) Regulation of the acetylcholine receptor and subunit gene by recombinant ARIA: an in vitro model for transynaptic gene regulation. Neuron 14:329-339, (Exhibit 9). . Corfas, G. et al., (1995) Differential expression of ARIA isoforms in the rat brain. Neuron 14:103-115 (Exhibit 10). . Falls, D.L. et al., (1993) ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family. Cell 72:801-815 (Exhibit 11). . Ho, W-H, et al., (1995) Sensory and motor neuron-derived factor. J. of Biol. Chem. 270(24) :14523-14532 (Exhibit 12). . Holmes, W.E. et al., (1992) Identification of heregulin, a specific activator of p185.sup.erbB2 . Science 256:1205-1210 (Exhibit 13). . Kuo, Y. et al., (1994) Isolation and characterization of chick and human nARIA, a novel member of the ERBB2/HER ligand family which lacks the immunoglobin domain. Soc. for Neurosc. Abstr. 20:1095. (Exhibit 14). . Kuo, Y. et al., (1993) Expression of members of the neu (ARIA) ligand family in chick and rat central nervous system. Soc. for Neurosc. Abstr. 19:1725 (Exhibit 15). . McGehee, D.S. et al., (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269:1692-1696 (Exhibit 16). . Mudge, A.W. et al., (1993) New ligands for neu? Current Biol. 3(6) :361-364 (Exhibit 17). . Sivilotti, L. and Colquhon, D. (1995) Acetylcholine receptors: too may channels, too few functions. Science 269:1681-1682 (Exhibit 18). . Vartanian, T. et al., (1994) A role for the acetylcholine receptor-inducing protein ARIA in oligodendrocyte development. PNAS, U.S.A. 91:11626-11630 (Exhibit 19). . Wen, D. et al., (1992) Neu differentiation factor: a transmembrane glycoprotein containing an EGF Domain and an immunoglobulin homology unit. Cell 69:559-572 (Exhibit 20). . Yang, X. et al., (1994) Identification of different ARIA splice variants expressed by chick cns and pns neurons during development. Soc. for the Neurosc. abstr. 20:1095 (Exhibit 21). . Wolpowitz, D. et al., Isoform Specific Knockout of Neuregulin-1 gene products: Selective Disruption of Only Cysteine-Rich Domain (CRD) -containing Isoforms, Mouse Genetics Conference, Cold Spring Harbor (1998) (Exhibit 23).. |