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United States Patent | 5,850,001 |
Kessous-Elbaz , et al. | December 15, 1998 |
The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the expression of the gene in the neuronal tissues of the mammal and effective for the simulation of neurological syndromes associated with HIV-1, the gene being introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammal is such that transcription of the env gene may be under the control of a promoter sequence, such as a neuron specific promoter of human neurofilament heavy gene (NFH). The promoter can be synthetic or inducible. The transgenic non-human mammal can be a rodent, such as a mouse.
Inventors: | Kessous-Elbaz; Allegria (Cote-St-Luc, CA), Michaud; Jean (Montreal, CA), Berrada; Fouad (Montreal, CA) |
Assignee: |
Universite de Montreal
(Montreal,
CA)
|
Appl. No.: | 08/685,708 |
Filed: | July 24, 1996 |
Application Number | Filing Date | Patent Number | Issue Date | ||
254395 | Jun., 1994 | 5569827 | |||
Current U.S. Class: | 800/11 ; 536/23.1; 800/18 |
Current International Class: | C12N 15/85 (20060101); C07K 14/005 (20060101); C07K 14/16 (20060101); C12N 015/00 (); C07H 021/02 () |
Field of Search: | 800/2 |
5569827 | October 1996 | Kessous-Elbaz |
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