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United States Patent | 6,159,709 |
Korneluk , et al. | December 12, 2000 |
The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
Inventors: | Korneluk; Robert G. (Ottawa, CA), Holcik; Martin (Ottawa, CA), Liston; Peter (Ottawa, CA) |
Assignee: |
Apoptogen, Inc.
(Ottawa,
CA)
|
Appl. No.: | 09/121,979 |
Filed: | July 24, 1998 |
Current U.S. Class: | 435/69.1 ; 435/320.1; 435/6; 435/70.1; 435/91.1; 536/23.1; 536/24.3; 536/24.31; 536/24.33 |
Current International Class: | C07K 14/435 (20060101); C12Q 1/68 (20060101); C12N 15/67 (20060101); C07K 14/47 (20060101); A61K 048/00 (); C07H 021/02 (); C07H 021/04 (); C12P 021/06 (); C12N 015/00 () |
Field of Search: | 536/24.1,23.1,24.3 435/6,91.1,440,375,320.1 514/44 |
5358856 | October 1994 | Baltimore et al. |
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