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United States Patent | 5,948,658 |
Landry | September 7, 1999 |
Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementarity determining regions and framework regions. The present invention also discloses a pharmaceutical composition and a method for decreasing the concentration of cocaine in a subject. Finally, the invention discloses pharmaceutical compositions and methods for treating cocaine overdose and addiction in subjects.
Inventors: | Landry; Donald W. (South New York, NY) |
Assignee: |
The Trustees of Columbia University in the City of New York
(New York,
NY)
|
Appl. No.: | 08/672,345 |
Filed: | June 25, 1996 |
Current U.S. Class: | 435/188.5 |
Current International Class: | C12N 9/00 (20060101); A61K 38/00 (20060101); C12N 009/00 () |
Field of Search: | 435/188.5 |
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