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United States Patent | 6,307,024 |
Novak , et al. | October 23, 2001 |
The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
Inventors: | Novak; Julia E. (Bainbridge Island, WA), Presnell; Scott R. (Tacoma, WA), Sprecher; Cindy A. (Seattle, WA), Foster; Donald C. (Lake Forest Park, WA), Holly; Richard D. (Seattle, WA), Gross; Jane A. (Seattle, WA), Johnston; Janet V. (Seattle, WA), Nelson; Andrew J. (Shoreline, WA), Dillon; Stacey R. (Seattle, WA), Hammond; Angela K. (Maple Valley, WA) |
Assignee: |
ZymoGenetics, Inc.
(Seattle,
WA)
|
Appl. No.: | 09/522,217 |
Filed: | March 9, 2000 |
Current U.S. Class: | 530/351 ; 424/143.1; 424/145.1; 435/69.1; 435/69.7; 530/350 |
Current International Class: | C07K 14/435 (20060101); C07K 14/52 (20060101); A61K 38/00 (20060101); C07K 014/00 (); C12P 021/06 (); C12P 021/04 (); A61K 039/395 () |
Field of Search: | 530/380,351 435/69.1,69.7 424/143.1,145.1 |
6057128 | May 2000 | Donaldson et al. |
Novak et al., Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function (2000), vol. 408, pp:57-63.. |