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United States Patent | 5,036,053 |
Himmelsbach , et al. | July 30, 1991 |
The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism, and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, composition containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertensions, or hyperaldosteronism.
Inventors: | Himmelsbach; Richard (San Jose, CA), Hodges; John C. (Ann Arbor, MI), Kaltenbronn; James S. (Ann Arbor, MI), Patt; William C. (Chelsea, MI), Repine; Joseph T. (Ann Arbor, MI), Sircar; Ila (Ann Arbor, MI) |
Assignee: |
Warner-Lambert Company
(Morris Plains,
NJ)
|
Appl. No.: | 07/321,638 |
Filed: | March 15, 1989 |
Application Number | Filing Date | Patent Number | Issue Date | ||
199990 | May., 1988 | ||||
Current U.S. Class: | 514/15.8 ; 514/15.7; 514/16.4; 514/21.91; 544/106; 544/383; 560/9; 564/79 |
Current International Class: | C07D 233/54 (20060101); C07D 233/00 (20060101); C07K 5/065 (20060101); C07K 5/00 (20060101); A61K 38/00 (20060101); A61K 037/02 () |
Field of Search: | 514/17,18,19 530/330,331,332 544/106,383 560/9 564/79 |
4845079 | July 1989 | Luly et al. |
Burger, Medicinal Chemistry, 1960, pp. 565-571, 578-581, 600-601. . Denkewalter et al., Progress in Drug Research. 1966, vol. 10, pp. 510-512. . Plattner et al., J. Med. Chem., 1988, 31(12), 2277-2288.. |