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United States Patent | 4,410,515 |
Holick , et al. | October 18, 1983 |
A synthetic compound which is biologically active in maintaining calcium and phosphorous metabolism in animals, of the formula I ##STR1## wherein the double bond between positions C-22 and C-23 is single or double; R.sup.2 is hydrogen, CH.sub.3 or CH.sub.2 CH.sub.3 ; X is selected from the group consisting of hydrogen and --OR.sup.1, where R.sup.1 is hydrogen or a straight or branched chain glycosidic residue containing 1-20 glycosidic units per residue; with the proviso that at least one of the R.sup.1 is a glycosidic residue.
Inventors: | Holick; Sally A. (Sudbury, MA), Holick; Michael F. (Sudbury, MA) |
Assignee: |
Massachusetts General Hospital
(Boston,
MA)
|
Appl. No.: | 06/249,922 |
Filed: | April 1, 1981 |
Current U.S. Class: | 514/35 ; 536/17.2; 536/18.1; 536/4.1; 536/53; 536/55.2; 568/665; 568/817; 568/819 |
Current International Class: | C07H 15/00 (20060101); C07H 15/18 (20060101); C07H 15/207 (20060101); C07H 015/20 (); C07H 015/18 () |
Field of Search: | 536/4,17.2,18.1,4.1 568/665,817,819 424/180 |
4188345 | February 1980 | DeLuca et al. |
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