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United States Patent | 5,686,419 |
Powers , et al. | November 11, 1997 |
Peptidyl derivatives of diesters of .alpha.-aminoalkylphosphonic acids with basic substitutents, their use in inhibiting serine proteases with trypsin-like specificity and their roles as anti-inflammatory agents, anticoagulants, and anti-tumor agents.
Inventors: | Powers; James C. (Atlanta, GA), Boduszek; Bogdan (Wroclaw, PL), Oleksyszyn; Jozef (Arlington, MA) |
Assignee: |
Georgia Tech Research Corp.
(Atlanta,
GA)
|
Appl. No.: | 08/184,286 |
Filed: | January 21, 1994 |
Current U.S. Class: | 514/13.7 ; 514/20.1; 514/20.3; 530/331; 530/345; 562/445 |
Current International Class: | C07K 5/08 (20060101); C07F 9/00 (20060101); C07F 9/40 (20060101); C07K 5/06 (20060101); C07K 5/00 (20060101); A61K 38/00 (20060101); A61K 038/06 () |
Field of Search: | 514/18,19,7 562/445 530/331,345 |
9207869 | May., 1992 | WO | |||
Fastrez, Tetrahedr Lett 30, 6861, 1989. . Oleksyszyn Bioch Biophys Res Comm 161, 143, 1989.. |
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