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United States Patent | 4,059,593 |
Kende , et al. | November 22, 1977 |
Steganacin and Steganangin, dibenzocyclooctadiene lignan lactones, have been reported to possess anti-leukemic activity. This invention describes the first total synthesis of these compounds and other relevant intermediates.
Inventors: | Kende; Andrew S. (Pittsford, NY), Liebeskind; Lanny S. (Snyder, NY) |
Assignee: |
University of Rochester
(Rochester,
NY)
|
Appl. No.: | 05/715,487 |
Filed: | August 18, 1976 |
Application Number | Filing Date | Patent Number | Issue Date | ||
642954 | Dec., 1975 | 4003916 | |||
Current U.S. Class: | 549/297 ; 549/430 |
Current International Class: | C07D 317/00 (20060101); C07D 317/54 (20060101); C07D 317/70 (20060101); C07D 317/60 (20060101); C07D 317/44 () |
Field of Search: | 260/340.5,34.5R |
becker et al., J. Chem. Soc., Chem. Commun., pp. 430-431 (1974). . Hughes et al., Tetrahedron Letters, No. 18, pp. 1543-1546 (May, 1976). . Kende et al., J. Am. Chem. Soc. 98, pp. 267-268 (1976).. |