( 323 of 323 ) |
United States Patent | 4,499,082 |
Shenvi , et al. | February 12, 1985 |
Peptides comprising C-terminal .alpha.-aminoboronic acid residues are potent, reversible inhibitors of proteolytic enzymes.
Inventors: | Shenvi; Ashokkumar B. (Wilmington, DE), Kettner; Charles A. (Wilmington, DE) |
Assignee: |
E. I. Du Pont de Nemours and Company
(Wilmington,
DE)
|
Appl. No.: | 06/558,362 |
Filed: | December 5, 1983 |
Current U.S. Class: | 514/20.4 ; 260/1; 514/20.1; 514/20.3; 514/21.9; 514/506; 530/331; 562/7; 930/10; 930/23; 930/250 |
Current International Class: | C07F 5/00 (20060101); C07K 5/08 (20060101); C07F 5/02 (20060101); C07K 5/00 (20060101); C07K 5/06 (20060101); A61K 38/00 (20060101); A61K 037/00 (); A61K 031/44 (); C07C 103/52 () |
Field of Search: | 424/263,177 260/112.5R |
4369183 | January 1983 | Jones |
2040291A | Aug., 1980 | GB | |||
Leinhard, Enzyme Inhibitors as Drugs, Sandler, Ed., (University Park Press, Baltimore, 1980), pp. 43-51. . Koehler et al., Biochemistry 10:2477 (1971). . Matteson et al., J. Am. Chem. Soc. 103:5241 (1981). . Lindquist et al., Arch. Biochem. Biophys. 160:135 (1974). . Lindquist et al., J. Am. Chem. Soc. 99:6435 (1977). . Powers et al., Biochim. Biophys. Acta. 485:156 (1977). . Kleinerman et al., Am. Rev. Resp. Dis. 121:381 (1980). . Janoff et al., Am. Rev. Resp. Dis. 121:1025 (1980). . Stone et al., Am. Rev. Resp. Dis. 124:56 (1981). . Powers et al., Biochem. Biophys, Res. Comm. 67:639 (1975). . Lestienne et al., J. Biol. Chem. 254:5219 (1979). . Teshima et al., J. Biol. Chem. 257:5085 (1982). . Yoshimura et al., J. Biol. Chem. 257:5077 (1982). . U.S. Patent Application Serial No. 558,361.. |