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United States Patent | 7,067,135 |
Balaban | June 27, 2006 |
The invention features methods and compositions for treatment or prevention of infection by, or disease caused by infection with, Staphylococcus spp., particularly S. aureus.
Inventors: | Balaban; Naomi (Davis, CA) |
Appl. No.: | 09/839,695 |
Filed: | April 19, 2001 |
Application Number | Filing Date | Patent Number | Issue Date | ||
09054331 | Apr., 1998 | 6291431 | |||
60068094 | Dec., 1997 | ||||
Current U.S. Class: | 424/190.1 ; 424/165.1; 424/184.1; 424/185.1; 424/9.34; 424/93.42; 435/199; 514/44R; 530/388.2; 530/388.21; 536/23.7 |
Current International Class: | A61K 39/02 (20060101); A61B 5/055 (20060101); A61K 39/00 (20060101); A61K 39/38 (20060101); A61K 39/40 (20060101) |
Field of Search: | 424/9.2,130.1,150.1,184.1,185.1,190.1,234.1,278.1,282.1,9.34,91.51,93.42,165.1 930/10,200 514/44 530/388.2,388.21 536/23.7 |
0 395 099 | Oct., 1990 | EP | |||
WO96/10579 | Apr., 1996 | WO | |||
WO 96 10579 | Apr., 1996 | WO | |||
WO97/44349 | Nov., 1997 | WO | |||
WO 97 44349 | Nov., 1997 | WO | |||
WO 99/32133 | Jul., 1999 | WO | |||
WO 99 32133 | Jul., 1999 | WO | |||
Balaban et al. 1998. Science. vol. 280 : 438-440. cited by examiner . Balaban et al. 1995. PNAS. vol. 92:1619-1623. cited by examiner . Lee.1998. Trends in Micrbiol. vol. 6(12):461-463. cited by examiner . Balaban et al., "Autocrine regulation of toxin synthesis by Staphylococcus aureas" Proc.Natl. Acad. Sci. USA (1995) 92:1619-1623. cited by other . Balaban et al., "Translation of RNAIII, the Staphylococcus aureas agr regulatory RNA molecule, can be activated by a 3'-end deletion" FEMS Microbiol. Letters (1995) 133:155-161. cited by other . Balaban et al., "Autoinducer of Virulence As a Target for Vaccine and Therapy Against Staphylococcus aereus" Science (1998) 280:438-440. cited by other . Ji, et al. "Cell Density Control of Staphylococcus Virulence Mediated by an Octapeptide Pheromone," Proc. Natl. Acad. Sci. USA (1995) 92:12055-12059. cited by other . Mayville, et al. "Structure-Activity Analysis of Synthetic Autoinducing Thiolactone Peptides form Staphylococcus aureus Responsible for Virulence," Proc. Natl. Acad. Sci. USA (1999) 96:1218-1223. cited by other. |