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United States Patent | 7,790,867 |
Bentwich | September 7, 2010 |
The present invention relates to a group of viral RNA regulatory genes, here identified as "viral genomic address messenger genes" or "VGAM genes", and as "genomic record" or "GR" genes. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a pervasive viral attack mechanism. GR genes encode an operon-like cluster of VGAM genes. VGAM and viral GR genes may therefore be useful in diagnosing, preventing and treating viral disease. Several nucleic acid molecules are provided respectively encoding several VGAM genes, as are vectors and probes, both comprising the nucleic acid molecules, and methods and systems for detecting VGAM genes, and for counteracting their activity.
Inventors: | Bentwich; Itzhak (Kfar Daniel, IL) |
Assignee: |
Rosetta Genomics Inc.
(Rehovot,
IL)
|
Appl. No.: | 10/604,943 |
Filed: | August 28, 2003 |
Application Number | Filing Date | Patent Number | Issue Date | ||
60441241 | Jan., 2003 | ||||
Current U.S. Class: | 536/23.1 ; 435/375; 435/6; 536/24.5 |
Current International Class: | C07H 21/02 (20060101); C07H 21/04 (20060101); A61K 31/70 (20060101); A01N 43/04 (20060101); C12N 5/00 (20060101); C12Q 1/68 (20060101) |
Field of Search: | 702/2 424/199.1,93.2 435/6,375 536/23.1,24.5 800/298 |
5744140 | April 1998 | Paoletti et al. |
6107091 | August 2000 | Cowsert |
6506559 | January 2003 | Fire et al. |
6903247 | June 2005 | Aldwinckle et al. |
2001/0053519 | December 2001 | Fodor et al. |
2002/0086356 | July 2002 | Tuschl et al. |
2004/0146910 | July 2004 | Zhou |
WO 0130362 | May., 2001 | WO | |||
WO 01/68836 | Sep., 2001 | WO | |||
WO 02/44321 | Jun., 2002 | WO | |||
WO 02/094185 | Nov., 2002 | WO | |||
WO 02088162 | Nov., 2002 | WO | |||
WO 2005001128 | Jan., 2005 | WO | |||
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